About this item
Doctor's Best Sustained plus Immediate Release L-Arginine contains this conditionally essential amino acid in a bilayer tablet, with two tablets providing 500 mg of sustained release and 500 mg of immediate release L-arginine in a formula that allows for enhanced blood levels of this nutrient. Most supplemental L-arginine is quickly absorbed into circulation and is extremely efficiently metabolized, yielding only a short-lived boost to L-arginine levels. Doctors Best Sustained plus Immediate Release L-Arginine tablets are specifically manufactured to immediately increase blood levels of L-arginine and then to sustain this beneficial increase continuously over an 8-hour period. L-arginine has been shown to support the cardio- vascular system, promote vigorous heart function and enhance healthy circulation throughout the body through its conversion to nitric oxide. Research suggests L-arginine supplementation may also have positive benefits on athletic performance. Science-based nutrition Dietary supplement Promotes a healthy cardiovascular system Enhances healthy circulation Supports heart function The normal aging process in humans has been found to be associated with progressive changes in endothelial function (cells that line the inner surfaces of blood vessels). Research suggests that a major reason for these common changes associated with aging is reduced production or bioavailability of nitric oxide (NO) in vessels and tissues (Bode-Boger et al. 2003). L-arginine is a substrate for the enzyme nitric oxide synthase, required for the production of nitric oxide in the body. Nitric oxide is a substance critical for the maintenance of normal vascular function (Brown and Hu 2001). NO mediates a number of physiological effects on the cardiovascular system, including supporting healthy endothelial function, enhancing cardiovascular health and displaying potent antioxidant properties against free radical species. Oral L-arginine supplementation has been shown in clinical studies to support various aspects of cardiovascular health. A randomized double-blind placebo-controlled trial found that six weeks of L-arginine supplementation enhanced circulation, improved arterial compliance and supported healthy heart function compared to placebo. The mechanism of L-arginine?s effect was due to its role in NO production. Other clinical trials have shown that oral L-arginine supplementation contributes to enhanced exercise tolerance because of its ability to enhance cardiac circulation and vasodilation of blood vessels (Appleton 2002). Multiple clinical trials have been conducted in which L-arginine at various doses has been administered to healthy individuals to assess its impact on cardiovascular function and health. In one such study, L-arginine enrichment of the diet in healthy individuals was shown to cause a reduction in arterial blood pressure, while other studies in healthy individuals did not report this effect. However, the overall results of these and other clinical trials showed that long-term administration of this amino acid significantly enhanced endothelial function (Cylwik et al. 2005). The Benefits of Sustained Release Arginine L-arginine undoubtedly has many benefits for cardiovascular health. Studies show that arginine is metabolized extremely efficiently by the body and used as a precursor for nitric oxide formation. L-arginine reaches its highest concentration in the bloodstream within an hour of its use and then tends to taper off quickly (Miller 2006). For this reason, relatively large doses of this amino acid taken frequently throughout the day are required to produce positive results. Blood levels of arginine are quickly depleted and frequent replenishment is necessary to ensure its availability. Recent technological advancements have allowed for the development of sustained release forms of this beneficial amino acid. Sustained plus Immediate Release L-Arginine contains the amino acid L-arginine in the form of arginine alpha-keto-glutarate. The bilayer tablet design allows for the benefits of immediate arginine uptake, resulting in a quick spike in arginine concentration, along with the longer-term effects of sustained arginine blood levels through sustained release of this important amino acid. This allows for higher arginine blood levels for a continuous period of up to 8 hours. With increased and consistent blood levels, less L-arginine is required, the frequency of dosing necessary to maintain its benefits is reduced and the efficacy is maintained over a longer period of time ? all tangible benefits worth looking for in a quality L-arginine supplement.
L-Arginine (as 500mg immediate release and 500mg sustained release from L-Arginine alpha-Keto-Glutarate), Cellulose, vegetable stearins, magnesium stearate (vegetable source), silicon dioxide.
Take 2 tablets once or twice daily, away from food, or as directed by a nutritionally informed physician.